PUBLICATIONS

PUBLICATIONS:

Srinivasan, R., Mager, G.M., Ward, R.M., Mayer, J., and Svaren, J. The NAB2 corepressor interacts with the CHD4 subunit of the NuRD complex (2006) Journal of Biological Chemistry, in press [Abstract]

LeBlanc, S.E., Jang, S.W., Ward, R.M., Wrabetz, L., and Svaren, J. Direct Regulation of Myelin Protein Zero Expression by the Egr2 Transactivator (2006) Journal of Biological Chemistry, 281:5453-5460[Abstract]

LeBlanc, S.E., Srinivasan, R., Mager, G.M., Gillian-Daniel, A.L., Wrabetz, L. and Svaren, J. (2005) Regulation of lipid/cholesterol biosynthetic genes by Egr2/Krox-20 during peripheral nerve myelination. Journal of Neurochemistry, 93:737-748.[Abstract]

Gillian-Daniel, A.L. and Svaren, J.(2004) The Ddx20/DP103 Dead Box Protein represses transcriptional activation by Egr2/Krox-20. Journal of Biological Chemistry, 279:9056-63 [Abstract]

Venken, K., Di Maria, E., Bellone, E.,Balestra, P., Cassandrini, D., Mandich, P., DeJonghe, P., Timmerman, V., Svaren, J. (2002) Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. Neurogenetics, 4:37-41. [Abstract]

Nagarajan, R., Svaren, J., Le, N., Araki T., Watson, M., and Milbrandt, J. (2001) EGR2 mutations in inherited neuropathies dominant negatively inhibit myelin gene expression. Neuron, 30:355-368 Full text

Svaren, J., Ehrig, T., Abdulkadir, S.A., Ehrengruber, M.U., Watson, M.A., and Milbrandt, J.(2000) EGR1 Target Genes in Prostate Carcinoma Cells identified by Microarray Analysis. Journal of Biological Chemistry 275,38524-38531. Full text

Sevetson, B., Svaren, J., and Milbrandt, J. (2000) A Novel Activation Function for NAB Proteins in EGR-dependent Transcription of the Luteinizing Hormone (LH ) Gene. Journal of Biological Chemistry 275, 9749-9757. Abstract Full Text

Warner, L.E., Svaren, J., Milbrandt, J., and Lupski, J.R. (1999) Functional consequences of mutations in the early growth response 2 (EGR2) gene associated with human myelinopathies. Human and Molecular Genetics 8, 1245-1251. Abstract

Svaren, J., Sevetson, B.R., Golda, T., Stanton, J., Swirnoff, A.H., and Milbrandt, J. (1998) Novel Mutants of NAB Corepressors Enhance Activation by Egr Transactivators. EMBO Journal 17, 6010-6019. Abstract Full Text

Svaren, J. and Hörz, W. (1997) Transcription factors vs. Nucleosomes: regulation of the PHO5 promoter in yeast. Trends in Biochemical Sciences 22, 93-97. Abstract

Svaren, J., Sevetson, B.R., Apel, E.D., Zimonjic, D.B., Popescu, N.C., and Milbrandt, J. (1996) NAB2, a Corepressor of NGFI-A (Egr-1) and Krox20, is Induced by Proliferative and Differentiative Stimuli. Molecular and Cellular Biology 16, 3545-3553. Abstract Full Text

Svaren, J. and Hörz, W. (1996) Regulation of Gene Expression by Nucleosomes. Current Opinion in Genetics and Development 6, 164-170. Abstract

Houston, P., Campbell, C.J., Svaren, J., Milbrandt, J., Braddock, M. (2001) The transcriptional corepressor nab2 blocks egr-1-mediated growth factor activation and angiogenesis. Biochem Biophys Res Commun 283:480-6

Abdulkadir, S.A., Qu, Z., Garabedian, E., Song, S.K., Peters, T.J., Svaren, J., Carbone, J.M., Naughton, C.K., Catalona, W.J., Ackerman, J.J., Gordon, J.I., Humphrey, P.A., Milbrandt, J. (2001) Impaired prostate tumorigenesis in Egr1-deficient mice. Nature Medicine 7, 101-107

Then Bergh, F., Flinn, E.M., Svaren, J., Wright, A.P., and Hörz, W. (2000) Comparison of Nucleosome Remodeling by the Yeast Transcription Factor Pho4 and the Glucocorticoid Receptor. Journal of Biological Chemistry, 275:9035-9042.

Dorn, C., Ou, Q., Svaren, J., Crawford, P.A., Sadovsky, Y. (1999) Activation of luteinizing hormone-b gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1. Journal of Biological Chemistry 274, 13870-13876.

Swirnoff, A.H., Apel, E.D., Svaren, J., Sevetson, B.R., Zimonjic, D.B., Popescu, N.C., and Milbrandt, J. (1998) Nab1, a Corepressor of NGFI-A (Egr-1), contains an Active Transcriptional Repression Domain. Molecular and Cellular Biology 18, 512-524.

Qu, Z., Wolfraim, L.A., Svaren, J., Ehrengruber, M.U., Davidson, N. and Milbrandt, J. (1998) The Transcriptional Corepressor NAB2 Inhibits NGF-induced Differentiation of PC12 Cells. Journal of Cell Biology 142, 1075-1082

McAndrew, P.C., Svaren, J., Martin, S.R., Hörz, W., and Goding, C.R.(1998) Requirements for Chromatin Modulation and Transcription Activation by the Pho4 Acidic Activation Domain. Molecular and Cellular Biology 18, 5818-5827

Svaren, J., Apel, E.D., Simburger, K.S., Jenkins, N.A., Gilbert, D.J., Copeland, N.A., and Milbrandt, J. (1997) The Nab2 and Stat6 Genes Share a Common Transcription Termination Region. Genomics 41, 33-39.

Barbaric, S., Münsterkötter, M., Svaren, J., and Hörz, W. (1996) The Homeodomain Protein Pho2 and the bHLH Protein Pho4 Bind DNA Cooperatively at the Yeast PHO5 Promoter. Nucleic Acids Research 24, 4479-4486.

Svaren, J., Venter, U., and Hörz, W. (1995) "In Vivo Analysis of Nucleosome Structure and Transcription Factor Binding in Saccharomyces cerevisiae" in Methods in Molecular Genetics: Molecular Microbiology Techniques, Part B, Academic Press.

Hager, G., Smith, C., Svaren, J., and Hörz, W. (1995) "Initiation of Expression: Remodelling Genes" in Chromatin Structure and Gene Expression, ed. S. Elgin, IRL Press Frontiers in Molecular Biology, ed. D. Glover and D. Hames.

Svaren, J. and Hörz, W. (1995) Interplay Between Nucleosomes and Transcription Factors at the Yeast PHO5 Promoter, Seminars in Cell Biology 6, 177-183.

Svaren, J., Klebanow, E., Sealy, L., and Chalkley, R. (1994) Analysis of the Competition Between Nucleosome Formation and Transcription Factor Binding. Journal of Biological Chemistry 269, 9335-9344.

Svaren, J., Wineinger, B., and Chalkley, R. (1994) Extent of In Vivo Binding by an Upstream Activation Factor and the Role of Multiple Binding Sites in Synergistic Transcriptional Activation. Journal of Biological Chemistry 269, 20771-20779.

Ventner, U., Svaren, J., Schmitz, J., and Hörz, W. (1994) A Nucleosome Precludes Binding of the Transcription Factor Pho4 to its Target site In Vivo. EMBO Journal 13, 4848-4855.

Svaren, J., Schmitz, J. and Hörz, W. (1994) The Transactivation Domain of Pho4 is Required for Nucleosome Disruption at the PHO5 Promoter. EMBO Journal 13, 4856-4862.

Svaren, J., and Hörz, W. (1993) Histones, Nucleosomes and Transcription. Current Opinion in Genetics and Development 3, 219-225.

Svaren, J., and Chalkley, R. (1990) The Structure and Assembly of Active Chromatin. Trends in Genetics 6, 52-56.

Gelb, M.H., Svaren, J., and Abeles, R.H. (1985) Fluoro Ketone Inhibitors of Hydrolytic Enzymes. Biochemistry 24, 1813-17.

Svaren, J., Inagami, S., Lovgren, E., and Chalkley, R. (1987) DNA Denatures Upon Drying After Ethanol Precipitation. Nucleic Acids Research 15, 8739-54.