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Role of prolactin in mammary cancer Prolactin receptors, signaling and processing Prolactin actions on fetal and maternal tissues during pregnancy
Graduate Training and Other Affiliations
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Linda
Schuler
Prolactin and its placental homologues modulate numerous processes which facilitate fetal development, maternal adaptations to pregnancy and preparations for postnatal care, including mammary gland development and lactation, as well as disease events in these same target tissues at other times in life. We are interested the determinants of cell and context specific actions, including ligand specificity, receptor signal transduction, receptor processing and cross talk with other signaling pathways. A second area of interest is cytokine action, especially IL-1, including cell specific control of expression of ligands, receptors and signal transduction. Together, these areas allow us to examine hormonal, growth factor and cytokine interactions in the modulation of physiologic and pathogenic processes. Click on the individual research topics in the sidebar to read their descriptions and pertinent publications. |
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