Home > Program Faculty >Curtis Smith Laboratory
Dr. Smith's major area of expertise concerns the neural control of breathing and cardiovascular function. Specific areas of investigation include:
- The role of peripheral chemoreceptors in the control of breathing during wakefulness and sleep.
- The role of peripheral chemoreceptors in the control of regional blood flow during exercise and hypoxia.
- The determinants of the apneic threshold for CO 2 during sleep.
- The effects of chronic intermittent hypoxia on the control of breathing during sleep.
Smith, C.A., B.J. Chenuel, K.S. Henderson, and J.A. Dempsey. The apneic threshold during non-REM sleep in dogs: sensitivity of carotid body vs. central chemoreceptors. J. Appl Physiol (May 10, 2007). doi:10.1152/japplphysiol.00017.2007 [Abstract]
Stickland, M.K., J.D. Miller, C.A. Smith, and J.A. Dempsey. Carotid chemoreceptor modulation of regional blood flow distribution and vascular conductance during exercise in health and chronic heart failure. Circ. Res. 2007
[Abstract]
Miller, J.D., C.A. Smith, S.J. Hemauer, and J.A. Dempsey. The effects of inspiratory intrathoracic pressure production on the cardiovascular response to submaximal exercise in health and chronic heart failure. Am. J. Physiol. Heart Circ. Physiol. 292:H580-592, 2007. [Abstract]
Chenuel, B.J., C.A. Smith, J.B. Skatrud, K.S. Henderson, and J.A. Dempsey. Increased propensity for apnea in response to acute elevations in left atrial pressure during sleep in the dog. J. Appl. Physiol. 101:76-83, 2006. [Abstract]
Dempsey, J.A., L. Romer, J. Rodman, J. Miller, and C. Smith. Consequences of exercise-induced muscle work. Respir. Physiol. Neurobiol. 151:242-250, 2006. [Abstract]
Miller, J.D., S.J. Hemauer, C. A. Smith, M. Stickland, and J.A. Dempsey. Expiratory threshold loading impairs cardiovascular function in health and chronic heart failure during submaximal exercise J. Appl. Physiol. 101:213-227, 2006. [Abstract]
Smith, C.A, J.R. Rodman*, B.J.A. Chenuel**, K.S. Henderson, and J.A.Dempsey. Response time and sensitivity of the ventilatory response to CO 2 in unanesthetized dogs. J. Appl. Physiol. 100:13-19, 2006. This paper was selected to be the subject of the following invited editorial: Nattie, E.E. Why do we have both peripheral and central chemoreceptors? J. Appl Physiol. 100:9-10, 2006. [Abstract]
Dempsey, J., J. Skatrud, and C. Smith. Powerful stabilizing effect of CO 2 during CPAP treatment. Sleep 28:12-13, 2005.
Chenuel, B.J.**, C.A. Smith, K.S. Henderson, and J.A. Dempsey. Increased propensity for apnea via dopamine-induced carotid body inhibition in sleeping dogs. J. Appl. Physiol. 98 1732-1739, 2005.[Abstract]
Dempsey, J.A., C.A. Smith, T. Pryzbylowski**, B. Chenuel**, and H. Nakayama**. Invited Topical Review. The ventilatory responsiveness to CO 2 below eupnoea as a determinant of ventilatory stability in sleep. J. Physiol. (Lond.) 560: 1-11, 2004. [Abstract]
Chenuel, B.J.**, C.A. Smith, K.S. Henderson, and J.A. Dempsey. Increased propensity for apnea via dopamine-induced carotid body inhibition in sleeping dogs. J. Appl. Physiol. 98 1732-1739, 2005. [Abstract]
Rodman, J.R.*, K.S. Henderson, C.A. Smith, and J.A. Dempsey. Cardiovascular effects of the respiratory muscle metaboreflexes in dogs: rest and exercise. J. Appl. Physiol. 95:1159-1169, 2003. [Abstract]
Smith, C.A., H. Nakayama**, and J.A. Dempsey. The essential role of carotid body chemoreceptors in sleep apnea. Invited Review. Can. J. Physiol. Pharmacol. 81:774-779, 2003. [Abstract]
Nakayama, H.** C.A. Smith, J.R. Rodman*, J.B. Skatrud, and J.A. Dempsey. Carotid Body Denervation Eliminates Apnea in Response to Transient Hypocapnia. J. Appl. Physiol.94: 155-164, 2003. [Abstract]
Nakayama, H.**, C.A. Smith, J.R. Rodman*, J.B. Skatrud, and J.A Dempsey. Effect of ventilatory drive on CO 2 sensitivity below eupnea during sleep. Am. J. Respir. Crit. Care Med. 165:1251-1259, 2002. [Abstract]
Dempsey, J.A., C.A. Smith, C.R. Wilson**, P.R. Eastwood**, and M.C.K. Khoo. Sleep-induced respiratory instabilities. In: Sleep Apnea: Pathogenesis, Diagnosis, and Treatment, A.I. Pack, ed., vol. 166, Lung Biology in Health and Disease series, C. Lenfant, ed., Marcel Dekker, New York, pp.57-98, 2002.
Smith, C.A., J.A. Dempsey, and T.F. Hornbein. Control of Breathing. In: High Altitude, T.F. Hornbein and R.B. Schoene, eds., vol. 161, Lung Biology in Health and Disease series, C. Lenfant, ed., Marcel Dekker, New York, pp. 139-174, 2001.
Rodman, J.R.*, A.K. Curran**, K.S. Henderson, J.A. Dempsey and C.A. Smith. Carotid body denervation in dogs: Eupnea and the ventilatory response to hyperoxic hypercapnia. J. Appl. Physiol. 91:328-335, 2001.[Abstract]
Satoh, M.**, P.R. Eastwood**, C.A. Smith, and J.A. Dempsey. Nonchemical Elimination of Inspiratory Motor Output via Mechanical Ventilation in Sleep. Am. J. Respir. Crit. Care Med. 163:1356-64, 2001. [Abstract]
Eastwood, P.R.**, A.K. Curran**, C.A. Smith and, J.A. Dempsey. Hemodynamic effects of pressures applied to the upper airway during sleep. J. Appl. Physiol., 89:537-548, 2000.[Abstract]
Curran, A.K.**, J.R. Rodman*, P.R. Eastwood**, K.S. Henderson, J.A. Dempsey, and C. A. Smith. Ventilatory responses to specific CNS hypoxia in sleeping dogs. J. Appl. Physiol. 88:1840-1852, 2000. [Abstract]
NIH HL50531-09
Dr.C. Smith (PI)
3/1997-12/2008
Central and Peripheral Mechanisms of Sleep Apnea
NIH RO1 HL15469-31
Dr. J. Dempsey (PI)
Dr. C. Smith (Co-I)9/1972-3/2012
Cardiovascular Sequellae of Respiratory Muscle Work Veterans Administration
Merit Review
Dr. S. Barczi (PI)
Dr. C. Smith (Co-I)8/2000-9/2008
Sleep Apnea: Mechanism and Cerebrovascular Consequences
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Updated 06/29/2007