Home > Program Faculty > Nizar Jarjour Laboratory
Dr. Jarjour's research interests are focused on the pathogenesis of asthma, particularly the role of airway inflammation.
He has conducted studies of exercise-induced, nocturnal, viral-induced and antigen-driven asthma. The role of cytokines and cell-matrix interactions are the focus of ongoing studies of airway remodeling in asthma.
In addition, his laboratory is conducting studies of circadian regulation of airway inflammation with a focus on the role of fibronectin and its interaction with GM-CSF and eosinophils.
Other areas of interest include treatment of airway inflammation and modulation of cellular inflammation using anti-asthma drugs.
Jarjour NN. Nocturnal asthma. "Pulmonary & Critical Care Update." (In press).
Jarjour NN. "Leukotriene receptor antagonists in asthma. Seminars in Respiratory and Critical Care Medicine" (In preparation).
Jarjour NN. 'Pathogenesis of Asthma. Medical Clinics of North America.' (In preparation).
Kenyon NJ, Kelly EAB, Jarjour NN. 'Enhanced cytokine generation by peripheral blood mononuclear cells in allergic and asthma subjects.' Ann. Allergy Asthma Immunol. 85:115-20, 2000.
Jarjour NN, Gern JE, Kelly EAB, Swenson CA, Dick CR, Busse WW. 'The effect of an experimental rhinovirus 16 infection on bronchial lavage neutrophils."J. Allergy Clin. Immunol. 105:1169-77, 2000.
Kelly EAB, Busse WW, Jarjour NN. "Inhaled budesonide decreases airway inflammatory response to allergen." Am. J. Resp. Crit. Care Med. 162:883-90, 2000.
Kelly EAB, Busse WW, Jarjour NN. "Increased matrix metalloproteinase?9 in the airway after allergen challenge." Am. J. Resp. Crit. Care Med. 162:1157-61, 2000.
Poulter LW, Burke CM, Jarjour NN, Pyke SD. "Designing bronchial biopsy studies". Respiratory Medicine. 94:S3-S8, 2000.
Meerschaert J, Kelly EAB, Mosher DF, Busse WW, Jarjour NN. "Segmental antigen challenge increases fibronectin in bronchoalveolar lavage fluid." Am. J. Respir. Crit. Care Med. 159:619-625, 1999.
Jarjour NN, Enhorning G. "Antigen-Induced airway inflammation in atopic subjects generates dysfunction of pulmonary surfactant." Am. J Resp. Crit. Care Med. 160:336-41, 1999.
Jarjour NN. "Circadian variation in allergen and non-specific bronchial responsiveness in asthma." Chronobiology International 16:631-9, 1999.
NIH NHLB R01 HL 64066 Airway Remodeling in Asthma
$1,125,000
NIH NHLB R01 HL-64812 Fibronectin in Nocturnal Asthma.
$1,125,000