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Faculty
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Trainers:
The program consists of 16 trainers for 8 departments.
Gordon S. Mitchell, Ph.D. (Program Director) Professor and Chair - Comparative Bioscience Respiratory plasticity induced by intermittent hypoxia, neural injury or neurodegenerative disease Mechanisms of plasticity in the respiratory control system Mary Behan, Ph.D. (Primary trainer) Associate Dean for Research and Graduate Training, Professor - Comparative Biosciences Age and gender effects on respiratory control Ruth Benca, MD, Ph.D. (Secondary trainer) Professor - Psychiatry Central neural mechanisms regulating sleep/light interactions. She collaborates with Dr. Behan.
Nizar Jarjour, M.D. (Primary trainer) Professor - Medicine Airway smooth muscle control in humans Rebecca A. Johnson, DVM/PhD/DACVA (Secondary trainer) Clinical Assistant Professor - Surgical Sciences Control of breathing in neurological diseases Stephen Johnson, MD, Ph.D. (Primary trainer) Associate Professor - Comparative Biosciences Respiratory rhythm generation and plasticity Barbara Morgan, P.T., Ph.D. (Primary trainer) Professor - Orthopedics and Rehabilitation Cardiorespiratory responses to hypoxia and exercise William Schrage, Ph.D. (Secondary trainer) Assistant Professor - Kinesiology Cardiovascular responses to hypoxia in humans Curtis Smith, Ph.D. (Primary trainer) Senior Scientist - Population Health Sciences Ventilatory control during sleep John Svaren, Ph.D. (Primary trainer) Associate Professor - Comparative Biosciences Transcriptional regulation by hypoxia Giulio Tononi, M.D., Ph.D. (Secondary Trainer) Professor - Psychiatry Consciousness and its disorders, mechanisms and functions of sleep Jyoti Watters, Ph.D. (Primary Trainer) Associate Professor - Comparative Biosciences Cell signaling in hypoxia and hypoxia-induced gene expression Additional Faculty Assisting in Training
Steve Barczi, M.D.
Associate Professor of MedicineHannah Carey, PhD. Academic Program Director, Biotron. Professor - Comparative Biosciences Our research focuses on the physiology in hibernating mammals and its application to human and animal health. We study basic aspects of organ function during the seasonal hibernation cycle, and also use hibernators as models for endogenous protection against stress and trauma conditions, including cold storage of organs prior to transplantation, ischemia/reperfusion injury and seasonal fattening. Our current studies include metabolomic analysis to identify biomarkers of seasonal metabolic cycles in brain, liver and plasma; examination of gene expression and signaling pathways involved in cholesterol and lipid metabolism; and the role of the gut microbiota in hibernation. Naomi Chesler, Ph.D. Assistant Professor, Department of Biomedical Engineering Dr. Chesler is interested in bioengineering applications to the pulmonary circulation. She collaborates with Dr. Eldridge. Nadine Connor, Ph.D. Associate Professor - Assistant Professor, Division of Otolaryngology Dr. Conner is a collaborator of Dr. Behan’s, and investigates tongue muscle plasticity after repetitive activity. Burt Olson, Ph.D. Associate Professor Emeritus, Preventive Medicine Dr. Olson collaborates extensively with Mitchell and Bisgard in studies on developmental plasticity in ventilatory control, and with Behan, Morgan and multiple others in exposing rats to intermittent or sustained hypoxia. He is also expert at barometric plethysmography and has helped train many pre- and postdoctoral fellows to make ventilatory measurements in unanesthetized rodents. He is a Co-investigator on multiple grants with Bisgard, Behan, Morgan and Mitchell. Daniel Resnick, M.D. Associate Professor of Neurosurgery Dr. Resnick is expert in rodent models of spinal cord injury and has shared his equipment and expertise with multiple trainees Avtar Roopra , Ph.D. Assistant Professor - Neurology Dr. Roopra is expert in epigenetics and is currently collaborating with Mitchell concerning the impact of the NRSF/CtBP co-repressors of histone methylation state. It is hypothesized that this mechanism of gene regulation effectively couples glycolytic flux with BDNF (and other neuronal) gene expression. Masa Suzuki, Ph.D. Assistant Professor - Comparative Biosciences The long term research objective is to apply stem cell technology to expand integrative sciences in both basic and translational research. The current research focuses on elucidating mechanisms of brain development in mammals using stem cells and finding possible applications of these cells for neurodegenerative diseases. Dandan Sun, Ph.D. Professor of Neurosurgery Dr. Sun has considerable expertise concerning hypoxia and/or reoxygenation and their impact on channel function. She has been a valuable consultant, particularly to trainees using cell culture models of hypoxia and/or anoxia. Clive Svendsen, Ph.D. Professor of Anatomy, Neurology, Waisman Center Dr. Svendsen is expert in the biology of neural progenitor cells, and genetically modifies them to produce and secrete selected trophic factors. He and Dr. Mitchell are working to develop the rat model of ALS (over-expressing mutated SOD-1) for investigations of its respiratory impairment, compensatory plasticity and functional recovery following the implantation of trophic factor secreting progenitor cells. Steven Weber, Ph.D. Clinical Professor -Neurology and Medicine, Director Clinical Sleep Laboratory Dr. Weber is a sleep disorders specialist with many years of experience. All fellows who will conduct their research in sleep apnea, learn the intricacies of sleep staging via EEG interpretation from Dr. Weber. Justin Williams , Ph.D. Assistant Professor, Biomedical Engineering Dr. Williams collaborates with Dr. Johnson, helping to develop important technical approaches such as multiple electrode arrays (including analysis) and the utilization of microfluidics to harness selective drug applications in vitro. Ailaing Xie, M.D., Ph.D. Senior Scientist, Department of Medicine Dr. Xie is expert in sleep disordered breathing in human subjects and is a major part of many studies focused on this topic. She has interacted extensively with Drs. Skatrud and Dempsey over the years.
Trainers Emeriti:
Gerald Bisgard, DVM, Ph.D. Professor Emeritus - Comparative Biosciences Developmental plasticity in the carotid body
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Updated 11/13/2009
