Home > Program Faculty > Jerome Dempsey Laboratory
The major interests of the Dempsey laboratory are in pulmonary and more recently cardiopulmonary physiology as it occurs in unanesthetized animals and humans, with specific applications to the effects of sleep, exercise, hypoxia, acid-base disturbances and heart failure.
Currently, our specific research activities emphasize the following:
- Cardiopulmonary interactions in exercise.
- The effects of metaboreflexes from the respiratory muscles influencing sympathetic vasoconstrictor outflow and blood flow distribution.
- The effects of intrathoracic pressure on left heart stroke volume and venous return during exercise.
- Role of airway inflammation in healthy and asthmatic athletes in causing exercise-induced arterial hypoxemia.
- Influences of mechanical feedback (using mechanical ventilation during sleep) on the control of breathing and the resetting of the respiratory pattern generator in sleeping humans.
- Causes of unstable and periodic breathing in sleep. Does the apneic threshold change under varying conditions of background of changing ventilatory drive?
- Regulation of cerebral blood flow and its consequences to the control of breathing during sleep.
Smith CA, Chenuel BJ, Henderson KS, Dempsey JA.The Apneic Threshold During Non-Rem Sleep In Dogs: Sensitivity Of Carotid Body Vs. Central Chemoreceptors. J Appl Physiol. 2007 May 10; [Epub ahead of print] [Abstract]
Haverkamp HC, Dempsey JA, Pegelow DF, Miller JD, Romer LM, Santana M, Eldridge MW.Treatment of airway inflammation improves exercise pulmonary gas exchange and performance in asthmatic subjects. J Allergy Clin Immunol. 2007 Jul;120(1):39-47.[Abstract]
Stickland MK, Miller JD, Smith CA, Dempsey JA. Carotid chemoreceptor modulation of regional blood flow distribution during exercise in health and chronic heart failure.Circ Res. 2007 May 11;100(9):1371-8.[Abstract]
Amann M, Romer LM, Subudhi AW, Pegelow DF, Dempsey JA. Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans. J Physiol. 2007 May 15;581(Pt 1):389-403.[Abstract]
Romer LM, Miller JD, Haverkamp HC, Pegelow DF, Dempsey JA. Inspiratory muscles do not limit maximal incremental exercise performance in healthy subjects. Respir Physiol Neurobiol. 2007 Jun 15;156(3):353-61.[Abstract]
Katayama K, Amann M, Pegelow DF, Jacques AJ, Dempsey JA. Effect of arterial oxygenation on quadriceps fatigability during isolated muscle exercise. Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292(3):R1279-86. [Abstract]
Romer LM, Dempsey JA, Lovering A, Eldridge M. Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue. Adv Exp Med Biol. 2006;588:47-55.[Abstract]
Miller JD, Smith CA, Hemauer SJ, Dempsey JA. The effects of inspiratory intrathoracic pressure production on the cardiovascular response to submaximal exercise in health and chronic heart failure. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H580-92. [Abstract]
Romer LM, Haverkamp HC, Amann M, Lovering AT, Pegelow DF, Dempsey JA. Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans. Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R598-606. [Abstract]
Dempsey, J.A. and J.B. Skatrud. Apnea following mechanical ventilation may be caused by nonchemical neuromechanical influences. Am J Respir Crit Care Med. 163: 1297-1301, 2001.
Wetter, T., C.M. St. Croix, D.F. Pegelow, D.A. Sonetti, and J.A. Dempsey. Effects of exhaustive endurance exercise on pulmonary gas exchange and airway function in females. J Appl Physiol. (in press, 2001).
Sonetti, D., T.J. Wetter, D.F. Pegelow, and J.A. Dempsey. Effects of respiratory muscle training vs. placebo on endurance exercise performance. Resp Physiol. (in press, 2001).
Sheel, A.W., P.A. Derchak, and J.A. Dempsey. Exercise pulmonary physiology in health. In: Asthma and Exercise. (R. Lemanske, editor)(in press), 2001).
Dempsey, J.A., W. Sheel, A.Derchak, and C.A. Harms. Two types of pulmonary system limitations to exercise. Deutschke Zeitschriff Für Sportmedizin 51: 318-326, 2000.
M. Satoh, P.R. Eastwood, C.A. Smith and J.A. Dempsey. Non-chemical elimination of inspiratory motor output via mechanical ventilation in sleep. Am J Resp Crit Care Med. 163: 1356-1364, 2001.
Dempsey, J.A., and J.B. Skatrud. Apnea following mechanical ventilation may be caused by nonchemical neuromechanical influences. Invited Pro/Con Editorial. Am J Resp Crit Care Med. 163: 1297-1301, 2001.
Wetter, T.J. and J.A. Dempsey. Pulmonary System and Endurance Exercise. In: Endurance in Sport, Volume II of the Encyclopedia of Sports Medicine, Second Edition, edited by RJ. Shephard and P-O. Astrand, International Olympic Committee, pp. 52-67, 2000.
Peppard, P.E., T. Young, M. Palta, J. Dempsey, and J. Skatrud. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA, 284: 3015-3021, 2000.
Banzett, R.B., J.A. Dempsey, D.E. O'Donnell, and M.Z. Wamboldt. Symptom perception and respiratory sensation in asthma. Amer J Resp. Crit Care Med. 162: 1178-1182, 2000.
1RO1 HL62561 Causes of Sleep-Induced Breathing Instabilities
$1,296,055
T32 HL07654 Pulmonary Physiology and Pathophysiology
$1,158,245
RO1 HL15469
Human Ventilatory Adaptation-Merit Award (New Title as of July 1, 2001: Cardiovascular Sequellae of Respiratory Muscle Work)