Home > Program Faculty > Gerald Bisgard
The main interest remains oxygen-related (either hyperoxia or hypoxia) induced plasticity of the arterial chemoreceptors and their associated afferent innervation. Studies concerning the impact of chronic hyperoxia or hypoxia are performed during early postnatal development as well as in adults. The ventilatory and health-related consequences of oxygen-related plasticity of the arterial chemoreceptors are of interest. Dr. Bisgard has had extensive collaborations with the Dempsey, Smith, Olson and Mitchell labs.
Recent Publications:
Wang, Z.-Y., Keith, I.M., Beckman, M.J., Brownfield, M.S., Vidruk, E.H., Bisgard, G.E.
5-HT5a Receptors in the carotid body chemoreception pathway of rat. Neurosci. Letters.
278:9-12, 2000.Wang, Z.-Y., Baker, T.L., Keith, I.M., Bisgard, G.E. Continuous, but not episodic hypoxia,
induces CREB phosphorylation in rat carotid body type 1 cells. In: Oxygen Sensing: Molecule to Man. Eds. S. Lahiri, N.R. Prabhakar, and R.E. Forster. Kluwer Academic/Plenum Press. N.Y., 2000. Adv. Exp. Med. Biol. 475:631-635, 2000.Bisgard, G.E. (Invited Review) Carotid body mechanisms in acclimatization to hypoxia.
Respir. Physiol. 121:237-246, 2000.Herman, J.K., K.D. O'Halloran and G.E. Bisgard. Effect of 8-OH DPAT and ketanserin on
ventilatory acclimatization to hypoxia in awake goats. Respir. Physiol.124: 95-104, 2001.Wang, Z-Y., Keith, I.M., Olson, E.B. Jr., Vidruk, E.H., Bisgard, G.E. Expression of 5-HT3 receptors in primary sensory neurons of the petrosal gangion in rats. Auton. Neurosci. 95: 121-124, 2002.
Wang, Z-Y., Bisgard, G.E. Chronic hypoxia-induced morphological and neurochemical changes in the carotid body. Microsc. Res. Tech. 59: 168-177, 2002.
Herman, J.K., O’Halloran, K.D., Janssen, P.L., Bisgard, G.E. Dopaminergic excitation of the goat carotid body is mediated by the serotonin type 3 receptor subtype. Respir. Physiol. Neurobiol. 136: 1-12. 2003.
Bisgard, G.E., Olson, E.B. Jr., Wang, Z-y., Bavis, R.W., Fuller, D.D., Mitchell, G.S. Adult chemoafferent responses to hypoxia after 1, 2, and 4 weeks of postnatal hyperoxia. J. Appl. Physiol. 95: 946-953, 2003.
Bisgard GE, Olson EB Jr, Bavis RW, Wenninger J, Nordheim EV, Mitchell GS.
Carotid chemoafferent plasticity in adult rats following developmental hyperoxia.
Respir Physiol Neurobiol. 2005 Jan 15;145(1):3-11 [Abstract]Wang ZY, Bisgard GE. Postnatal growth of the carotid body. Respir Physiol Neurobiol. 2005 Nov 15;149(1-3):181-90 [Abstract]
Wenninger JM, Olson EB, Wang Z, Keith IM, Mitchell GS, Bisgard GE.Carotid sinus nerve responses and ventilatory acclimatization to hypoxia in adult rats following 2 weeks of postnatal hyperoxia. Respir Physiol Neurobiol. 2006 Feb 28;150(2-3):155-64.[Abstract]
Perinatal Hyperoxia and Adult Arterial Chemoreception.