work focuses on cell-cell interactions and their role in neuroplasticity
following spinal cord injury. An ultimate goal of this research
is to regulate neuron-glia interactions as a means of enhancing
spinal plasticity in spared motor pathways to respiratory motor
neurons following high cervical hemisection. Three main questions
are currently being pursued:
microglia, astrocytes and/or oligodendrocytes undergo morphological
changes suggesting activation in the spinal ventral horn
at distance from the hemisection?
glial cells produce growth and trophic factors that contribute
to neuroplasticity in spared motor pathways, potentially
contributing to functional recovery?
treatments that enhance or restrain glial injury responses
enhance recovery from spinal injury?