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Representative Publications UW Affiliations and Teaching Responsibility Former Postdocs and Graduate Students
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Publications R.J. Duescher and A.A. Elfarra. 1,3-Butadiene oxidation by human myeloperoxidase: Role of chloride ion in catalysis of divergent pathways. J. Biol. Chem., 267, 19859 (1992). [Abstract] R. Duescher, M. Lawton, R. Philpot, and A. Elfarra. Flavin-containing monooxygenase (FMO)-dependent metabolism of methionine and evidence for FMO3 being the major FMO involved in methionine sulfoxidation in rabbit liver and kidney microsomes. J. Biol. Chem., 269, 17525 (1994). [Abstract] A.A. Elfarra, R.J. Duescher, I.Y. Hwang, A.R. Sicuri, and A.J. Nelson. Targeting 6-thioguanine to the kidney with S-(guanin-6-yl)-L-cysteine. J. Pharmacol. Exp. Ther., 274, 1298 (1995). [Abstract] R. Krause and A. Elfarra. Oxidation of butadiene monoxide to meso- and (±)-diepoxybutane by cDNA-expressed human P450s and by mouse, rat, and human liver microsomes: Evidence for preferential hydration of meso-DEB in rat and human liver microsomes. Arch. Biochem. Biophys., 337, 176 (1997). [Abstract] S.L Ripp, K. Itagaki, R.M. Philpot, and A.A. Elfarra. Species and sex differences in expression of flavin-containing monooxygenase form 3 in liver and kidney microsomes. Drug Metab. Disops., 27, 46-52 (1999). [Abstract] [Full Text] R.R. Selzer and A.A. Elfarra. In vitro reactions of butadiene monoxide with single and double stranded DNA: Characterization and quantitation of several purine and pyrimidine adducts. Carcinogenesis, 20, 285-292 (1999). [Abstract] [Full Text] S.S. Gunnarsdottir and A.A. Elfarra. Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yeild the chemotheraputic drup 6-mercaptopurine: Evidence for two distinct mechanisms in rats. J. Pharmacol. Exp. Ther., 290, 950-957 (1999). [Abstract] [Full Text] [Full Text (PDF)] S.L Ripp, K. Itagaki, R.M. Philpot, and A.A. Elfarra. Methionine S-oxidation in human and rabbit liver microsomes: Evidence for a high-affinity methionine S-oxidase activity that is distinct from flavin containing monooxygenase 3. Arch. Biochem. Biophys., 367, 322-332 (1999). [Abstract] T.S. Moll, A.S. Harms and A.A. Elfarra. A comprehensive structural analysis of hemoglobin adducts formed after in vitro exposure of erythrocytes to butadiene monoxide. Chem. Res. Toxicol., 13, 1103-1113 (2000) [Abstract] [Full Text] R.A. Kemper, R.J. Krause, and A.A. Elfarra. Metabolism of butadiene monoxide by freshly isolated hepatocytes from mice and rats: different partitioning between oxidative, hydrolytic and conjugation pathways. Drug Metab. Dispos., 29, 830-836 (2001) [Abstract] [Full Text]
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